Hb J-Nyanza alpha21(B2)Ala->Asp
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves faster than Hb A on paper at alkaline pH (8.9)
CHROMATOGRAPHY Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GCT->GAT; alpha2 or alpha1
STABILITY Not reported
OCCURRENCE Found in a family from Western Kenya
OTHER INFORMATION Quantity in heterozygotes as high as 35% because of a co-existing alpha-thal
1. Kendall, A.G., Barr, R.D., Lang, A., and Lehmann, H.: Biochim. Biophys. Acta, 310:357, 1973.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.