Hb J-Kurosh alpha19(AB1)Ala->Asp
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves to the position of Hb J on cellulose acetate and starch gel
CHROMATOGRAPHY Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis of selected peptides
DNA ANALYSES Not reported; presumed mutation GCG->? (undefined); GCC-> GAC?; alpha2 or alpha1
STABILITY Not reported
OCCURRENCE Found in a healthy Iranian male
OTHER INFORMATION Quantity in the heterozygote 25%
NOTE Codon 19 is presumed to be GCG but may be GCC in some populations; a one base change of GCC can result in GAC and explain the Ala->Asp replacement
1. Rahbar, S., Ala, F., Akhavan, E., Nowzari, G., Shoa'i, I., and Zamanianpoor, M.H.: Biochim. Biophys. Acta, 427:119, 1976.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.