Hb J-Cubujuqui alpha141(HC3)Arg->Ser
CONTACT C-terminus
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves to the position of Hb J on starch gel and cellulose acetate at alkaline pH; moves like Hb A on citrate agar
CHROMATOGRAPHY Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; carboxypeptidase A
DNA ANALYSES Not reported; presumed mutation: CGT->AGT; alpha2 or alpha1
FUNCTIONAL STUDIES Increased oxygen affinity; decreased cooperativity and Bohr effect
OCCURRENCE Found in an Indian child living in Costa Rica and in a Mexican American
OTHER INFORMATION Quantity in heterozygotes 25-29%
1. Saenz, G.F., Elizondo, J., Alvarado, M.A., Atmetlla, F., Arroys, G., Martinez, G., Lima, F., and Colombo, B.: Biochim. Biophys. Acta, 494:48, 1977.
2. Moo-Penn, W.F., Therrell, B.L., Jr., Jue, D.L., and Johnson, M.H.: Hemoglobin, 5:715, 1981.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.