Hb J-Camagüey alpha141(HC3)Arg->Gly
CONTACT C-terminus
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves to the position of Hb J on starch gel at alkaline pH and by IEF
CHROMATOGRAPHY Hb X and Hb A separate by cation and anion exchange chromatography
STRUCTURE STUDIES Tryptic digeston; separation of peptides by fingerprinting; amino acid analysis; carboxypeptidase A
DNA ANALYSES Not reported; presumed mutation CGT->GGT; alpha2 or alpha1
STABILITY Slightly unstable
OCCURRENCE Found in a Cuban family of Spanish descent, a Chinese family, a family of Chinese-Australian origin, and a few Spanish families
OTHER INFORMATION Quantity in the heterozygotes 18-20%
1. Martinez, G., Lima, F., Residenti, C., and Colombo, B.: Hemoglobin, 2:47, 1978.
2. Fei, X., Yang, K-G., Liang, C-C., Huang, Y-W., Wang, R-X., and Zhang, N-J.: Hemoglobin, 8:397, 1984.
3. Brennan, S.O., Lowrey, I.R., Harris, M.G., Rodwell, R., Zarkos, K., Wilkinson, T., Yakas, J., and Kronenberg, H.: Hemoglobin, 15:303, 1991.
4. Romero, M.J., Garrido, M.L., Abril, E., Garrido, F., and de Pablos, J.Ma.: Hemoglobin, 19:287, 1995.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.