Hb J-Anatolia alpha61(E10)Lys->Thr
CONTACT External
HEMATOLOGY Probably normal in the heterozygote
ELECTROPHORESIS Hb X separates from Hb A at alkaline pH; starch gel showed a fast-moving band in the region of Hb J and a fast extra Hb A2 band
CHROMATOGRAPHY Hb X can be separated from Hb A by anion exchange HPLC
STRUCTURE STUDIES Tryptic peptides were isolated by reversed phase HPLC; the alphaXT-9 carried an extra threonine at the amino terminus; amino acid analysis; sequencing
DNA ANALYSES Mutation in the alpha2 gene: AAG->ACG at codon 61
FUNCTIONAL STUDIES Normal oxygen affinity
OCCURRENCE Found in a Turkish woman
OTHER INFORMATION Quantity in the heterozygote 27-28%
1. Giardano, P.C., Fodde, R., Amons, R., Ploem, J.E., and Bernini, L.F.: Hemoglobin, 14:119, 1990.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.