Hb Iwata alpha87(F8)His->Arg
CONTACT Heme contact; proximal histidine
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves slower than Hb A on starch gel and cellulose acetate at alkaline pH
CHROMATOGRAPHY Hb X was isolated on a DE-52 cellulose column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAC->CGC; alpha2 or alpha1
STABILITY Mildly unstable
OCCURRENCE Found in Japanese and Chinese families
OTHER INFORMATION Quantity in heterozygotes 5-10%; abnormal spectrum of oxy-Hb; spectrum of cyan-ferriHb is normal; variant carries two heme groups/tetramer
1. Ohba, Y., Miyaji, T., Hattori, Y., Fuyuno, K., and Matsuoka, M.: Hemoglobin, 4: 307, 1980.
2. Liu, G-Y., Zhang, G-X., Nie, S-Y., Luo, H-Y., Teng, Y-Q., Liu, S-P., Song, M., Son, L., Chen, S-S., Jia, P-C., and Liang, C-C.: Hemoglobin, 7:279, 1983.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.