Hb Inkster alpha85(F6)Asp->Val
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves to the position of Hb S on cellulose acetate at alkaline pH but like Hb A on citrate agar at acidic pH
CHROMATOGRAPHY Isolated on a DEAE-Sephadex or DEAE-cellulose column; good separation by cation exchange HPLC
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; cation exchange chromatography; amino acid analysis
DNA ANALYSES A GAC->GTC mutation at codon 85 in the alpha2 gene (Ref. 2)
FUNCTIONAL STUDIES Increased oxygen affinity
OCCURRENCE Found in an English-German family and in some Black families
OTHER INFORMATION Quantity in the heterozygote 21-23%; found in association with beta-thal
1. Reed, R.E., Winter, W.P., and Rucknagel, D.L.: Br. J. Haematol., 26:475, 1974.
2. Molchanova, T.P., Pobedimskaya, D.D., and Huisman, T.H.J., Br. J. Haematol., 88:300, 1994.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.