Hb Hopkins-II	alpha112(G19)His->Asp

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves slightly ahead of Hb A at alkaline pH and like Hb A on citrate agar
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES		Fingerprinting of tryptic and chymotryptic peptides; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation CAC->GAC; alpha2 or alpha1
FUNCTIONAL STUDIES		Normal in whole blood; increased oxygen affinity in isolated Hb X; decreased heme-heme interaction; normal Bohr effect
STABILITY		Unstable
OCCURRENCE		Found in a few Caucasian families
OTHER INFORMATION		Quantity in heterozygotes 17-27%; found in association with Hb S

REFERENCES
1.		Charache, S. and Ostertag, W.: Blood, 36:852, 1970.
2.		Charache, S., Ostertag, W., and von Ehrenstein, G.: Nature, 234:248, 1971.
3.		Clegg, J.B. and Charache, S.: Hemoglobin, 2:85, 1978.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.