Hb Harbin alpha16(A14)Lys->Met
CONTACT External
HEMATOLOGY Proband was anemic
ELECTROPHORESIS Hb X was identified as a fast-moving band with a mobility like Hb J; the variant moves ahead of Hb A at alkaline pH
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis of a few tryptic peptides
DNA ANALYSES Not reported; presumed mutation AAG->ATG; alpha2 or alpha1
FUNCTIONAL STUDIES Slightly increased oxygen affinity
STABILITY Slightly unstable
OCCURRENCE Found in a 30-year-old Chinese woman
OTHER INFORMATION Quantity in the heterozygote 18%
1. Zeng, Y-T., Huang, S-Z., Qiu, X-K., Cheng, G-C., Ren, Z-R., Jin, Q-C., Chen, C-Y., Jiao, C-T., Tang, Z-G., Liu, R-H., Bao, X-H., Zeng, L-Z., Duan, Y-Q., and Zhang, G-Y.: Hemoglobin, 8:569, 1984.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.