Hb Handa alpha90(FG2)Lys->Met
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves ahead of Hb A on starch gel at alkaline pH; moves anodally to Hb A on IEF
CHROMATOGRAPHY Hb X was isolated on a DEAE-cellulose column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation AAG->ATG; alpha2 or alpha1
FUNCTIONAL STUDIES Normal oxygen affinity, Bohr effect, and cooperativity
OCCURRENCE Found in Japanese families
OTHER INFORMATION Quantity in the heterozygote 17-19%
1. Harano, T., Harano, K., Shibata, S., Ueda, S., Imai, K., and Seki, M.: Hemoglobin, 6:379, 1982.
2. Sugihara, J., Imamura, T., Kagimoto, M., Matsuo, T., Yamada, H., Imoto, T., and Yanase, T.: Biochim. Biophys. Acta, 744:119, 1983.
3. Hidaka, K., Iuchi, I., Shimasaki, S., Mizuta, W., Takatsuka, M., Mori, T., Tohdoh, A., and Matsuo, M.: Hemoglobin, 10:65, 1986.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.