Hb G-Honolulu alpha30(B11)Glu->Gln
ALSO KNOWN AS G-Singapore; G-Chinese; G-Hong Kong
CONTACT alpha1beta1 contact
HEMATOLOGY Normal in heterozygotes
ELECTROPHORESIS Hb X moves about as Hb S at alkaline pH; no separation at acidic pH
CHROMATOGRAPHY Hb X separates from Hb A on cation and anion exchange HPLC
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAG->CAG; alpha2 or alpha1
STABILITY Not reported
OCCURRENCE Found in several Chinese families
OTHER INFORMATION Quantity in heterozygotes 12-15%
1. Vella, F., Ager, J.A.M., and Lehmann, H.: Nature, 182:460, 1958.
2. Schneider, R.G. and Jim, R.T.S.: Nature, 190:454, 1961.
3. Swenson, R.T., Hill, R.L., Lehmann, H., and Jim, R.T.S.: J. Biol. Chem., 237: 1517, 1962.
4. Zeng, Y.T., Huang, S.Z., Zhou, X.D., Feng, J.P., Chen, M.J., Sheng, M., Qiu, X.K., Tao, Y.J., Chen, B.F., Lam, H., Wilson, J.B., and Huisman, T.H.J.: Shanghai Med. J., 5:125, 1982.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.