Hb Fort de France alpha45(CE3)His->Arg
CONTACT External; heme contact
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH (moves as Hb S on cellulose acetate); good separation by IEF
CHROMATOGRAPHY Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES Tryptic digestion; peptides were separated by fingerprinting or cation exchange chromatography; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES Increased oxygen affinity; normal Bohr effect and cooperativity
OCCURRENCE Found in two unrelated families living in Martinique
OTHER INFORMATION Quantity in the heterozygote 20%; increased autoxidation
1. Braconnier, F., Gacon, G., Thillet, J., Wajcman, H., Soria, J., Maigret, P., Labie, D., and Rosa, J.: Biochim. Biophys. Acta, 493:228, 1977.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.