Hb Ferndown alpha6(A4)Asp->Val
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves between Hb A and Hb S but very close to Hb A at alkaline pH (8.9); it separates from Hb A on citrate agar at acidic pH
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GAC->GTC; alpha2 or alpha1
FUNCTIONAL STUDIES Increased oxygen affinity; Bohr and cooperativity effects normal
OCCURRENCE Found in a 40-year-old British woman
OTHER INFORMATION Quantity in the heterozygote 8%
1. Lee-Potter, J.P., Deacon-Smith, R.A., Lehmann, H., and Robb, L.: FEBS Lett., 126:117, 1981.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.