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CONTACT | |
External | |
HEMATOLOGY | |
Normal in the heterozygote | |
ELECTROPHORESIS | |
Hb X moves like Hb F on cellulose acetate (pH 8.4); it moves between Hb A and Hb S on citrate agar (pH 6.0) | |
CHROMATOGRAPHY | |
Hb X separates from Hb A by DEAE-Sephadex or DEAE-cellulose chromatography | |
STRUCTURE STUDIES | |
Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis; carboxypeptidase; sequencing | |
DNA ANALYSES | |
Not reported; presumed mutation GAC->AAC; alpha2 or alpha1 | |
FUNCTIONAL STUDIES | |
Increased oxygen affinity; Bohr and 2,3-DPG effects normal | |
STABILITY | |
Normal | |
OCCURRENCE | |
In Black, Indian, and Moroccan families | |
OTHER INFORMATION | |
Quantity in heterozygotes 11.6% | |
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REFERENCES |
1. | |
Jue, D.L., Johnson, M.H., Patchen, L.C., and Moo-Penn, W.F., Hemoglobin, 3: 137, 1979. | |
2. | |
Charache, S., Brimhall, B., and Zaatari, G., Am. J. Hematol., 9:151, 1980. | |
3. | |
Nakatsuji, T., Webber, B.B., Johnson, S.E.N., and Huisman, T.H.J.: Hemoglobin, 7:597, 1983. | |
4. | |
Baklouti, F., Francina, A., Dorléac, E., Baudin-Chich, V., Gombaud-Saintonge, G., Plauchu, H., Wajcman, H., Delaunay, J., and Godet, J.: Am. J. Hematol., 27: 253, 1988. | |