Hb Davenport alpha78(EF7)Asn->His
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves between Hb A and Hb F on IEF
CHROMATOGRAPHY Separation was obtained by cation exchange HPLC
STRUCTURE STUDIES Tryptic peptides were separated by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES An AAC->CAC mutation at codon 78 in the alpha1 gene (Ref. 2)
OCCURRENCE Found in a Caucasian family of German descent
OTHER INFORMATION Quantity in heterozygotes 19.5-21%
1. Wilson, J.B., Webber, B.B., Plaseska, D., de Alarcon, P.A., McMillan, S.K., and Huisman, T.H.J.: Hemoglobin, 14:599, 1990.
2. Molchanova, T.P., Pobedimskaya, D.D., and Huisman, T.H.J.: Br. J. Haematol., 88:300, 1994.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.