Hb Daneskgah-Tehran alpha72(EF1)His->Arg
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves to the position of Hb S on cellulose acetate and starch gel at alkaline pH; Hb X moves with Hb A on agar gel at pH 6.2
CHROMATOGRAPHY Hb X was isolated on a DEAE-cellulose column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting and reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAC->CGC; alpha2 or alpha1
OCCURRENCE Found in an Iranian and an Argentinean family
OTHER INFORMATION Quantity in heterozygotes 25%
1. Rahbar, S., Nowzari, G., and Daneshmond, P.: Nature New Biol., 245:268, 1973.
2. de Weinstein, B.I., Kutlar, A., Webber, B.B., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 9:409, 1985.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.