Hb Contaldo | alpha103(G10)His->Arg |
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CONTACT | alpha1beta1 contact | ||
HEMATOLOGY | Moderate hemolytic anemia in the heterozygote | ||
ELECTROPHORESIS | Hb X moves like Hb F at alkaline pH, between Hb S and Hb C on citrate agar at acidic pH, and close to Hb F on IEF | ||
CHROMATOGRAPHY | Hb X was isolated by DEAE-cellulose chromatography | ||
STRUCTURE STUDIES | Tryptic peptides of the oxidized alphaX chain were separated by reversed phase HPLC; amino acid analysis; sequence analyses of the core peptide | ||
DNA ANALYSES | Not reported; presumed mutation CAC->CGC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in an Italian child | ||
OTHER INFORMATION | Quantity in the heterozygote 15-20% |
REFERENCES | |||
1. | Sciarratta, G.V., Ivaldi, G., Molaro, G.L., Sansone, G., Salkie, M.L., Wilson, J.B., Reese, A.L., and Huisman, T.H.J.: Hemoglobin, 8:169, 1984. |