Hb Chongqing	alpha2(NA2)Leu->Arg

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Starch gel and cellulose acetate electrophoresis at alkaline pH showed a slowly-moving band corresponding to Hb G
CHROMATOGRAPHY		Hb X can be separated from Hb A by cation and anion exchange chromatography
STRUCTURE STUDIES		Hb X was identified by fingerprinting; peptide alphaT-1 had disappeared and two new peptide spots were observed because of the Leu->Arg substitution at position 2 of the alpha chain
DNA ANALYSES		Not reported; presumed mutation CTG->CGG; alpha2 or alpha1
FUNCTIONAL STUDIES		Increased oxygen affinity
STABILITY		Unstable
OCCURRENCE		In a Chinese family
OTHER INFORMATION		About 9% in heterozygotes

REFERENCES
1.		Zeng, Y-T., Huang, S-Z., Qiu, X-K., Cheng, G-C., Ren, Z-R., Jin, Q-C., Chen, C-Y., Jiao, C-T., Tang, Z-G., Liu, R-H., Bao, X-H., Zeng, L-Z., Duan, Y-Q., and Zhang, G-Y.: Hemoglobin, 8:569, 1984.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.