Hb Chicago alpha136(H19)Leu->Met
CONTACT Heme contact
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Two bands, migrating slightly slower than Hb F and Hb A, were observed on IEF, but not by any other electrophoretic method
STRUCTURE STUDIES The alphaX, beta and alpha chains readily separate by reversed phase HPLC; tryptic digestion; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES A CTG->ATG mutation at codon 136 of the alpha2 gene (Ref. 3)
OCCURRENCE Found in several Black families
OTHER INFORMATION Observed in a patient with sickle cell anemia
1. Bowman, J.E., Bloom, R., Chen, S.S., Webber, B.B., Wilson, J.B., Kutlar, F., Kutlar, A., and Huisman, T.H.J.: Hemoglobin, 10:495, 1986.
2. Gu, L-H., Wilson, J.B., Molchanova, T.P., McKie, K.M., McKie, V.C., and Huisman, T.H.J.: Hemoglobin, 17:295, 1993.
3. Molchanova, T.P., Pobedimskaya, D.D., and Huisman, T.H.J.: Br. J. Haematol., 88:300, 1994.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.