Hb Bari alpha45(CE3)His->Gln
CONTACT External; heme contact
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves with Hb A on cellulose acetate (pH 8.4) and on citrate agar
CHROMATOGRAPHY Hb X did not separate by DEAE-cellulose chromatography
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAC->CAG; alpha2 or alpha1
FUNCTIONAL STUDIES Normal oxygen affinity, Bohr effect, and cooperativity
OCCURRENCE Found in an Italian male
OTHER INFORMATION Quantity in the heterozygote was estimated at about 20%
1. Marinucci, M., Mavilio, F., Tentori, L., D'Erasmo, F., Colapietro, A., De Stasio, G., and Di Fonzo, S.: Biochim. Biophys. Acta, 622:315, 1980.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.