Hb Aztec alpha76(EF5)Met->Thr
CONTACT Internal
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS No separation observed at alkaline and acidic pH
CHROMATOGRAPHY Hb X and Hb A apparently do not separate by cation or anion exchange HPLC; the variant was detected as an abnormal alpha chain by reversed phase HPLC
STRUCTURE STUDIES Tryptic peptides were separated by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation ATG->ACG; alpha2 or alpha1
STABILITY Not reported
OCCURRENCE Found in a newborn and her mother of native Mexican and Spanish descent
1. Shelton, J.B., Shelton, J.R., Schroeder, W.A., and Powars, D.R: Hemoglobin, 9:325, 1985.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.