Table XII

TABLE XII.

Beta-Thalassemia Alleles in the Populations of Southeast Asian Countries (number of chromosomes) (references in parentheses)

[1] Burma Thailand Malaysia Singapore Indonesia

Allele
(1) Central North
(2,3) Northeast South Total Malay
(4) Chinese
(4) Malay
(3) Chinese
(3)
(5)

-86, C->G 2 2

-29, A->G 1

-28, A->G 4 35 4 1 16 56 3 8

+1, A->C 1 1 2 1 2 9

Initiation codon, T->G 1

Codons 8/9, +G 1 1 1

Codons 14/15, +G 1 1

Codon 15, -T 1 1

Codon 15, TGG->TAG 1 1 4

Codon 16, -C 1

Codon 17, A->T 7 62 45 13 32 152 7 2 12 1

Codon 19, A->G 11 43 54 10 3 1

Codon 26, G->T 1 1

Codons 27/28, +C 2 2 1

Codon 30, G->C 1

IVS-I-1, G->A 2 2 1

IVS-I-1, G->T 34 5 1 17 23 9 1 1 6

IVS-I-2, T->C 1

IVS-I-5, G->C 27 16 2 53 71 45 1 11 1 32

Codon 35, -C 4 1 1

Codon 35, C->A 10 10

Codon 41, -C 3 4 7

Codons 41/42, -TTCT 21 156 45 19 85 305 7 38 5 45 1

Codon 43, G->T 3 3 1

Codons 71/72, +A 8 8 16 2

Codon 95, +A 1 1

IVS-II-654, C->T 2 30 1 5 6 42 4 14 1 33 7

AATAAA->AATAGA 1 2

Hb Lepore 1 1

105 bp deletion 1 1

619 bp deletion 4 4

3.4 kb deletion 4 1 12 17

Unknown; others 4 19 15 3 8 45 8 0 4 0 5

TOTAL 99 373 113 51 282 819 99 72 31 102 59

[1] May include a few subjects of Indian origin.

1. Brown, J.M., Thein, S.L., Weatherall, D.J., and Mar, K.M.: Br. J. Haematol., 81:574, 1992.

2. Laosombat, V., Fucharoen, S-P., Panich, V., Fucharoen,G., Wongchanchailert, M., Sriroongrueng, W., Nopparatana, C., Kenpitak, K., Maipang, M., and Fukumaki, Y.: Am. J. Hematol., 41:194, 1992.

3. Fucharoen, S. and Winichagoon, P.: Hemoglobin, in press, 1997.

4. George, E., Li, H-J., Fei, Y-J., Reese, A.L., Baysal, E., Cepreganova, B., Wilson, J.B., Gu, L-H., Nechtman, J.F., Stoming, T.A., Liu, J-C., Codrington, J.F., and Huisman, T.H.J.: Hemoglobin, 16:51, 1992.

5. Lie-Injo, L.E., Cai, S.P., Wahidijat, L., Moeslichan, S., Lim, M.L., Evangelista, L., Doherty, M., and Kan, Y.W.: Am. J. Hum. Genet., 45:971, 1989.

This material is from the book A Syllabus of Thalassemia Mutations (1997) by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1997 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without permission in writing from the Author.

[1]	Burma	Thailand					Malaysia		Singapore		Indonesia
Allele	(1)	Central	North (2,3)	Northeast	South	Total	Malay (4)	Chinese (4)	Malay (3)	Chinese (3)	(5)
-86, C->G		2				2
-29, A->G								1
-28, A->G	4	35	4	1	16	56	3	8
+1, A->C					1	1	2	1	2	9
Initiation codon, T->G										1
Codons 8/9, +G					1	1			1
Codons 14/15, +G		1				1
Codon 15, -T		1				1
Codon 15, TGG->TAG					1	1					4
Codon 16, -C									1
Codon 17, A->T	7	62	45	13	32	152	7	2		12	1
Codon 19, A->G		11			43	54	10	3	1
Codon 26, G->T				1		1
Codons 27/28, +C		2				2			1
Codon 30, G->C											1
IVS-I-1, G->A					2	2					1
IVS-I-1, G->T	34	5		1	17	23	9	1	1		6
IVS-I-2, T->C							1
IVS-I-5, G->C	27	16	2		53	71	45	1	11	1	32
Codon 35, -C							4		1		1
Codon 35, C->A		10				10
Codon 41, -C		3			4	7
Codons 41/42, -TTCT	21	156	45	19	85	305	7	38	5	45	1
Codon 43, G->T		3				3				1
Codons 71/72, +A		8		8		16		2
Codon 95, +A		1				1
IVS-II-654, C->T	2	30	1	5	6	42	4	14	1	33	7
AATAAA->AATAGA							1		2
Hb Lepore							1	1
105 bp deletion					1	1
619 bp deletion		4				4
3.4 kb deletion		4	1		12	17
Unknown; others	4	19	15	3	8	45	8	0	4	0	5
TOTAL	99	373	113	51	282	819	99	72	31	102	59

1.	Brown, J.M., Thein, S.L., Weatherall, D.J., and Mar, K.M.: Br. J. Haematol., 81:574, 1992.
2.	Laosombat, V., Fucharoen, S-P., Panich, V., Fucharoen,G., Wongchanchailert, M., Sriroongrueng, W., Nopparatana, C., Kenpitak, K., Maipang, M., and Fukumaki, Y.: Am. J. Hematol., 41:194, 1992.
3.	Fucharoen, S. and Winichagoon, P.: Hemoglobin, in press, 1997.
4.	George, E., Li, H-J., Fei, Y-J., Reese, A.L., Baysal, E., Cepreganova, B., Wilson, J.B., Gu, L-H., Nechtman, J.F., Stoming, T.A., Liu, J-C., Codrington, J.F., and Huisman, T.H.J.: Hemoglobin, 16:51, 1992.
5.	Lie-Injo, L.E., Cai, S.P., Wahidijat, L., Moeslichan, S., Lim, M.L., Evangelista, L., Doherty, M., and Kan, Y.W.: Am. J. Hum. Genet., 45:971, 1989.