TABLE IX. | Beta-Thalassemia Alleles in Several Middle Eastern Populations (number of chromosomes) (references in parentheses) |
Jordan | Syria | Saudi Arabia | Yemen | United Arab Emirates | Kuwait | Iran | S.W. Iran | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Allele | (1,2) | (3) | (1) | (1) | (1) | UAE | Others[1] (4,5) | Kuwait (5) | Others[2] (6) | (7) | (8) |
-101, C->T | 1 | 1 | |||||||||
-88, C->A | 1 | 1 | |||||||||
-87, C->G | 2 | ||||||||||
+1, A->C | 1 | 3 | |||||||||
Initiation codon, ATG->ATT | 1 | ||||||||||
Codon 5, -CT | 3 | 11 | 6 | ||||||||
Codon 6, -A | 1 | 4 | |||||||||
Codon 8, -AA | 10 | 16 | 7 | 4 | |||||||
Codons 8/9, +G | 3 | 1 | 15 | 27 | 3 | 5 | |||||
Codon 15, TGG->TAG | 2 | 10 | |||||||||
Codon 16, -C | 9 | ||||||||||
Codon 19, A->G[3] | 1 | ||||||||||
Codons 22/23/24, -AAGTTGG | 2 | ||||||||||
Codon 27, G->T[4] | 3 | 2 | |||||||||
Codon 29, C->T | |||||||||||
Codon 30, AGG->ACG[5] | 6 | 4 | |||||||||
Codon 30, AGG->AAG | 2 | ||||||||||
Codon 30, AGG->AGC[6] | 1 | ||||||||||
IVS-I-1, G->A | 2 | 6 | 6 | 6 | 7 | 4 | |||||
IVS-I-1, G->T | 7 | ||||||||||
IVS-I-5, G->C | 5 | 12 | 138 | 150 | 18 | 8 | |||||
IVS-I-6, T->C | 2 | 6 | 8 | 1 | 7 | 5 | 3 | ||||
IVS-I-110, G->A | 15 | 20 | 16 | 25 | 6 | 5 | 2 | 8 | 7 | 2 | |
IVS-I-130, G->A | 1 | ||||||||||
Codons 36/37, -T | 1 | 11 | 1 | 2 | |||||||
Codon 37, TGG->TGA | 8 | 1 | |||||||||
Codon 39, C->T | 2 | 4 | 12 | 10 | 10 | 7 | 12 | 6 | 1 | ||
Codons 41/42, -TTCT | 5 | ||||||||||
Codon 44, -C | 4 | 6 | 1 | 3 | |||||||
Codons 47/48, +ATCT | 1 | ||||||||||
Codons 57/58, +C | 1 | ||||||||||
Codons 82/83, -G | 3 | ||||||||||
IVS-II-1, G->A | 3 | 18 | 1 | 12 | 4 | 9 | 19 | 28 | 3 | 15 | 6 |
IVS-II-1, G->C | 2 | ||||||||||
IVS-II-654, C->T | 1 | ||||||||||
IVS-II-745, C->G | 2 | 11 | 6 | 2 | 9 | 2 | |||||
IVS-II-848, C->A | 2 | 1 | |||||||||
Codon 110, T->C | 2 | ||||||||||
Poly A, AATAAA->AATAAG | 2 | ||||||||||
Poly A, AATAAA->A- - - - - | 2 | ||||||||||
Unknown; others | 12 | 4 | 3 | 14 | 5 | 0 | 0 | 0 | 0 | 40 | 2 |
TOTAL | 39 | 91 | 36 | 81 | 15 | 229 | 296 | 89 | 24 | 114 | 18 |
[1] Hb Malay [beta19(B1)Asn->Ser].
[2] Hb Knossos [beta27(B9)Ala->Ser].
[3] Hb Monroe [beta30(B12)Arg->Thr].
[4] Hb Tacoma [beta30(B12) Arg->Ser].
[5] Pakistani; Indian; Bangladeshi; Iranian; Omani; etc.
[6] Bedouin; Egyptian; Palestinian; Indian; Lebanese.
1. | El-Hazmi, M.A.F., Warsy, A.S., and Al-Swailem, A.R.: Hemoglobin, 19:353, 1995. |
2. | El-Hazmi, M.A.F. and Al-Swailem, A.R.: Hum. Hered., 37:211, 1987. |
3. | Sadiq, M.F.G. and Huisman, T.H.J.: Hemoglobin, 18:325, 1994. |
4. | El-Kalla, S. and Mathews, A.R.: Hemoglobin, 17:355, 1993. |
5. | El-Kalla, S. and Mathews, A.R.: Hemoglobin, 21:237, 1997. |
6. | Adekile, A.D., Gu, L-H., Baysal, E., Haider, M.Z., Al-Fuzae, L., Aboobacker, K.C., Al-Rashied, A., and Huisman, T.H.J.: Acta Haematol., 92:176, 1994. |
7. | Nozari, G., Rahbar, S., Golshaiyzan, A., and Rahmandzadeh, S.: Hemoglobin, 19:425, 1995. |
8. | Merat, A., Haghshenas, M., Mostafavi Pour, Z., Plonczynski, M.W., Harrell, A.N., Coleman, M.B., and Steinberg, M.H.: Hemoglobin, 17:427, 1993. |