This group of conditions is characterized by deletions involving at least part of the delta- and beta-globin genes. Often the deletion is much larger and includes the entire delta and beta genes, and sometimes the Agamma or the Agamma, Ggamma, and epsilon genes. The phenotype of the heterozygote is comparable to that of a beta°-thal. Four different groups are recognized:
V-a. The GgammaAgamma(deltabeta)°-thal alleles;(Globin genes listed between parentheses are part of the deletion.)
V-b. The Lepore Hbs;
V-c. The Ggamma(Agammadeltabeta)°-thal alleles;
V-d. The (epsilongammadeltabeta)°-thal alleles.