HbVar: A Database of Human Hemoglobin Variants and Thalassemias
Help Page

History page

This page uses a browser cookie to keep track of the queries that are run at HbVar for each user. The user's queries can then be combined using the provided operations to ask more complex questions than can be done through the query form alone. If you have problems with the history make sure that cookies are enabled in your browser.

Examples

PhenCode has examples which include HbVar as well as other related web sites.

Text boxes

The program searches for what you type within the entry. For example if you type "Hb S" in Hb name box it will return Hb S as well as Hb Shelby and others. It looks for exactly what you type with the exception of letter case. It is better to type less instead of more if you are unsure of the exact wording used. To continue with the earlier example Hb S will not be found if you type "HbS" or "Hb   S"(3 spaces) or "Hemoglobin S".
In the text boxes you can look for more than one item by typing an AND or OR between the items you are searching for. For example you can type "Hb G-Philadelphia or Hb D-Baltimore" if you are not certain which name the variant is listed under. The case of the words AND and OR does not matter but there must be at least one space before and after the word.

Selection boxes

Unless the selection box says Select one you can select multiple items. How you do this varies with the various computer platforms. For Netscape and Internet Explorer:

• Windows/PC (Windows 95/98/NT): Hold down the "control" key while clicking the mouse. This key is labeled "Ctrl" on the keyboards for our PCs. If you hold down the "shift" key, all items between the first and second choices will be selected.
  To make corrections you must "start over" and click on the first item you wish to select and the rest will automatically be unselected. Then continue to select as before. If you decide to not select any items in this box then select the blank space.
• MacOS/Macintosh: Hold down the "command/apple" key while clicking the mouse. This is the key with the apple on it. If you hold down the "shift" key, all items between the first and second choices will be selected.
  To make corrections you must "start over" and click on the first item you wish to select and the rest will automatically be unselected. Then continue to select as before. If you decide to not select any items in this box then select the blank space.
• Unix: Click on as many items as needed each will be added. To remove an item click on it a second time.

Even for the boxes where you select only one, the blank space can be used to unselect a previous choice.

Display formats

The Summary table displays the variants name, residue number, and mutation or insertion and/or deletion as a link to the rest of the data in a page display format. The Page display format displays the first variant that fits your query. There is also a UCSC Genome Browser custom track option, a tab-separated text file, and a simplified HGVS nomenclature output options. The tab-separated text has genome coordinates making it compatible for use with Galaxy. The simplified HGVS nomenclature is another computer friendly output explained here.

Numbering systems

The mutation data is stored using the GenBank reference sequences NG_000006.1 and NG_000007.3. Several numbering systems can be used for queries. For more explanation click here.

Javascript

Some javascript is used on these pages. It is mostly used to open and close sections of the form to keep the display simple. If you have trouble opening the form sections, make sure javascript is enabled in your browser.