A Database of Human Hemoglobin Variants and Thalassemias
This is a relational database of information about hemoglobin variants and
mutations that cause thalassemia. The initial data came from
authored by Prof. Titus H.J. Huisman, Mrs. Marianne F.H. Carver,
Dr. Erol Baysal, and Prof. Georgi D. Efremov.
This information was converted to a database, and now new entries are added
and old entries are corrected by our curators, Dr. Henri Wajcman,
Dr. George Patrinos, Dr. Kamran Moradkhani, Joseph Borg, and Philippe Joly.
HbVar results from a collaboration among several investigators
at Penn State University (USA), INSERM Creteil (France), and Boston
University Medical Center (USA). Visit our query
page or summary page to see the types of information available.
To access summaries of the categories of the mutations, click here.
Summaries of mutation categories
has counts of the results for common queries and buttons to link to them.
Most recent update
Difference in mass chart
XPRbase has experimental protocols
Search FINDbase for beta allele frequencies
Search FINDbase for alpha allele frequencies
Search FINDbase for delta allele frequencies
Note: You may have to install Silverlight software to view the FINDbase pages.
Help with numbers
Help with HGVS nomenclature
Frequently Asked Questions (including how to add a new variant to HbVar)
How to contact us
- Number of users from January 27, 2000 to July 5, 2014
- Query page 84,681
Summary page 47,798
Html syllabus 223,355
- Number of users from April 5, 2012 to July 5, 2014
- LOVD - Globin Gene Server 18,263
Databases of Human Hemoglobin Variants and Other Resources at the
Globin Gene Server.
HbVar: A relational database of human hemoglobin variants and thalassemia mutations at the globin gene server:
Improvements in the HbVar database of human hemoglobin variants and thalassemia
mutations for population and sequence variation studies.
HbVar Database of Human Hemoglobin Variants and Thalassemia Mutations:
Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach.
table (.xls) and
SeqView, a Sequence Visualisation Program
PhenCode - connects data from LSDBs (including HbVar) to genome browsers.
LOVD version of the Globin Gene Server
(this includes some genes not in HbVar)
Most of this material is derived from the books
A Syllabus of Human Hemoglobin Variants (Second Edition, 1998)
by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov,
A Syllabus of Thalassemia Mutations (1997)
by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal,
both published by
The Sickle Cell Anemia Foundation in Augusta, GA, USA.
Obtaining a printed copy
Citing this resource*
*Patrinos, G.P., B. Giardine, C. Riemer, W. Miller, D.H.K. Chui, N.P.
Anagnou, H. Wajcman, and R.C. Hardison (2004)
Improvements in the
HbVar database of human hemoglobin variants and thalassemia mutations
for population and sequence variation studies. Nucl. Acids Res . 32
Database issue: D537-541.