Hb Vicksburg | beta75(E19)Leu->0 |
---|
HEMATOLOGY | Microcytosis and hypochromia in the heterozygote | ||
ELECTROPHORESIS | No separation observed | ||
CHROMATOGRAPHY | Hb X can be isolated on a DEAE-Sephadex column from the proband's lysate which contained Hb F and Hb A2 and no Hb A; Hb X moves like Hb A | ||
STRUCTURE STUDIES | Tryptic digestion of betaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported | ||
FUNCTION STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a 6-year-old Black male and presumably in his mother | ||
OTHER INFORMATION | Quantity in the heterozygote not reported; found in association with beta+-thal |
REFERENCES | |||
1. | Adams, J.G., III, Steinberg, M.H., Newman, M.V., Morrison, W.T., Benz, E.J., Jr., and Iyer, R.: Proc. Natl. Acad. Sci. USA, 78:469, 1981. |