Hb Saint-Antoine | beta74(E18)-beta75(E19) Gly-Leu->0 |
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HEMATOLOGY | Mild hemolytic anemia in the heterozygote | ||
ELECTROPHORESIS | No separation obtained at alkaline pH | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | pCMB; digestion of AE-betaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported | ||
FUNCTION STUDIES | Normal or nearly normal | ||
STABILITY | Slightly unstable | ||
OCCURRENCE | Found in a 25-year-old female of Mediterranean origin | ||
OTHER INFORMATION | None |
REFERENCES | |||
1. | Najman, A., Duhamel, G., Andre, R., Buc, H., Wajcman, H., Labie, D., and Schapira, G.: Nouv. Rev. Fr. d'Hematol., 13:803, 1973. | ||
2. | Wajcman, H., Labie, D., and Schapira, G.: Biochim. Biophys. Acta, 295:495, 1973. |