Hb Coventry | beta141(H19)Leu->0 (probably incorrect: |
---|---|
Suggested Leu->Hydroxyleu) |
HEMATOLOGY | No hematological abnormalities | ||
ELECTROPHORESIS | No separation of Hb X and Hb A | ||
CHROMATOGRAPHY | No separation reported | ||
STRUCTURE STUDIES | pCMB; tryptic digestion; separation of peptides by fingerprinting or HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported | ||
FUNCTION STUDIES | Increased oxygen affinity? | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in several families and is widespread | ||
OTHER INFORMATION | The Hb Coventry anomaly always occurs in association with another unstable Hb (Hb Sydney, Hb Atlanta); it is likely incorrectly identified as a deletion of leucine at beta141; more likely is oxidation to hydroxyleucine [see Hb Atlanta; beta75 (E19)Leu->Pro] |
REFERENCES | |||
1. | Casey, R., Kynoch, P.A.M., Lang, A., Lehmann, H., Nozari, G., and Shinton, N.K.: Br. J. Haematol., 38:195, 1978. | ||
2. | Nozari, G., Rahbar, S., and Lehmann, H.: FEBS Lett., 95:88, 1978. | ||
3. | Brennan, S.O., Williamson, D., Symmans, W.A., and Carrell, R.W.: Hemoglobin, 7:303, 1983. |