Hb F-Cincinnati | Ggamma41(C7)Phe->Ser |
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ELECTROPHORESIS | Hb FX did not separate from Hb F at alkaline pH | ||
IEF | Hb FX did not separate from Hb F by IEF | ||
CHROMATOGRAPHY | Not reported | ||
CHAIN SEPARATION | GgammaX = 29.5%; Ggamma = 37%; Agamma = 33.5% | ||
STRUCTURE STUDIES | Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | A TTC->TCC mutation at codon 41 | ||
NOTES | Found in a Caucasian newborn with cyanosis; baby became normal when Hb F disappeared after birth |
REFERENCES | |||
1. | Kholi-Kumar, M., Zwerdling, T., and Rucknagel, D.L.: Am. J. Hematol., 49:43, 1995. |