Hb A2-Fitzroy | delta142(H20)Ala->Asp |
---|
CONTACT | External; central cavity; 2,3-DPG pocket | ||
ELECTROPHORESIS | Hb X moves between Hb S and Hb A2 at alkaline pH | ||
IEF | About the same | ||
CHROMATOGRAPHY | Hb X was isolated by DEAE-Sephadex chromatography | ||
STRUCTURE ANALYSIS | Tryptic digestion of Hb X; separation of peptides by fingerprinting; amino acid analysis; sequencing | ||
DNA ANALYSIS | Not reported; presumed mutation GCC->GAC at codon 142 | ||
NOTES | Found in a Greek family |
REFERENCES | |||
1. | Williamson, D., Brennan, S.O., Strosberg, H., Whitty, J., and Carrell, R.W.: Hemoglobin, 8:325, 1984. |