Hb A2-Coburg | delta116(G18)Arg->His |
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CONTACT | External | ||
ELECTROPHORESIS | Hb X moves slightly faster than Hb S at alkaline pH | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Hb X was isolated by DEAE-cellulose chromatography | ||
STRUCTURE ANALYSIS | Tryptic digestion of AE-deltaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing | ||
DNA ANALYSIS | Not reported; presumed mutation CGT->CAT at codon 116 | ||
NOTES | Found in a Sicilian family in association with beta-thal |
REFERENCES | |||
1. | Sharma, R.S., Williams, L., Wilson, J.B., and Huisman, T.H.J.: Biochim. Biophys. Acta, 393:379, 1975. |