Hb A2-Babinga | delta136(H14)Gly->Asp |
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CONTACT | Central cavity | ||
ELECTROPHORESIS | Hb X moves slightly faster than Hb A2 at alkaline pH | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Hb X separates from Hb A2 on an anion exchange column | ||
STRUCTURE ANALYSIS | Tryptic digestion of AE-delta chain; separation of peptides by fingerprinting or cation exchange HPLC; amino acid analysis; sequencing | ||
DNA ANALYSIS | Not reported; presumed mutation GGT->GAT at codon 136 | ||
NOTES | Found in Babinga Pygmies (frequency 1-2%) and also in a few Black families |
REFERENCES | |||
1. | De Jong, W.W.W. and Bernini, L.F.: Nature, 219:1360, 1968. | ||
2. | Huisman, T.H.J., Reynolds, C.A., Dozy, A.M., and Wilson, J.B.: Biochim. Biophys. Acta, 175:223, 1969. | ||
3. | McRoyan, D.K., Liu, P.I., Mankad, V.N., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 8:413, 1984. |